MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis

During V(D)J recombination of immunoglobulin genes, p53 and nonhomologous end-joining (NHEJ) suppress aberrant rejoining of DNA double-strand breaks induced by recombinase-activating genes (Rags)-1/2, thus maintaining genomic stability and limiting malignant transformation during B-cell development....

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Main Authors: Johnson, Radia M., Papp, Eniko, Grandal, Ildiko, Kowalski, Paul E., Nutter, Lauryl, Wong, Raymond C.C., Joseph-George, Ann M., Danska, Jayne S., Guidos, Cynthia J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052764/
https://ncbi.nlm.nih.gov/pubmed/24888589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.240820.114
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