Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis

In fibrotic diseases caveolin-1 underexpression in fibroblasts results in collagen overexpression and in monocytes leads to hypermigration. These profibrotic behaviors are blocked by the caveolin-1 scaffolding domain peptide (CSD) which compensates for caveolin-1 deficiency. Monocytes and fibroblast...

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Hlavní autoři: Lee, Rebecca, Perry, Beth, Heywood, Jonathan, Reese, Charles, Bonner, Michael, Hatfield, Corey M., Silver, Richard M., Visconti, Richard P., Hoffman, Stanley, Tourkina, Elena
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052341/
https://ncbi.nlm.nih.gov/pubmed/24966836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00140
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