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Retromer arrests receptor on the run
Parathyroid hormone analogue PTH(1–34), used clinically to treat osteoporosis, forms a stable complex with its receptor and prolongs cAMP production even after internalization and recruitment to endosomes. New data suggests this signaling cascade is stimulated by β-arrestins and terminated by retrom...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4052209/ https://ncbi.nlm.nih.gov/pubmed/21502946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.564 |
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