Intracellular Cleavage of Amyloid β by a Viral Protease NIa Prevents Amyloid β-Mediated Cytotoxicity

Nuclear inclusion a (NIa) of turnip mosaic virus is a cytosolic protease that cleaves amyloid β (Aβ) when heterologously overexpressed. Lentivirus-mediated expression of NIa in the brains of APP(sw)/PS1 mice significantly reduces cerebral Aβ levels and plaque depositions, and improves behavioral def...

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Bibliographic Details
Main Authors: Shin, Baehyun, Oh, Hyejin, Park, Sang Min, Han, Hye-Eun, Ye, Michael, Song, Woo Keun, Park, Woo Jin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051590/
https://ncbi.nlm.nih.gov/pubmed/24915567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098650
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