Systemic Delivery of MicroRNA-181b Inhibits Nuclear Factor-κB Activation, Vascular Inflammation, and Atherosclerosis in Apolipoprotein E–Deficient Mice

RATIONALE: Activated nuclear factor (NF)-κB signaling in the vascular endothelium promotes the initiation and progression of atherosclerosis. Targeting endothelial NF-κB may provide a novel strategy to limit chronic inflammation. OBJECTIVE: To examine the role of microRNA-181b (miR-181b) in endothel...

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Hlavní autoři: Sun, Xinghui, He, Shaolin, Wara, A.K.M., Icli, Basak, Shvartz, Eugenia, Tesmenitsky, Yevgenia, Belkin, Nathan, Li, Dazhu, Blackwell, Timothy S., Sukhova, Galina K., Croce, Kevin, Feinberg, Mark W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051320/
https://ncbi.nlm.nih.gov/pubmed/24084690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.302089
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