A Phase II study of cisplatin preceded by a 12-h continuous infusion of concurrent hydroxyurea and cytosine arabinoside (Ara-C) for adult patients with malignant gliomas (Southwest Oncology Group S9149)

Inhibition of DNA excision repair can modulate resistance to cisplatin. Cytosine arabinoside (Ara-C) and hydroxyurea (HU), in combination, inhibit the excision-repair system and removal of platinum-DNA adducts. Marked cytotoxic synergy had been demonstrated in vitro at clinically achievable levels....

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Swinnen, Lode J., Rankin, Cathryn, Carraway, Hetty, Albain, Kathy S., Townsend, Jeannette J., Budd, George Thomas, Kish, Julie A., Rivkin, Saul E., Blumenthal, Deborah T.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051205/
https://ncbi.nlm.nih.gov/pubmed/18175205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-007-9483-3
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares