Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss

BACKGROUND: Notch signaling plays a crucial role in the fate determination of cochlear progenitor cells, hair cells, and supporting cells in the developing cochlea. Recent studies have demonstrated the temporal activation of Notch signaling in damaged mature cochleae, and have demonstrated the induc...

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Main Authors: Tona, Yosuke, Hamaguchi, Kiyomi, Ishikawa, Masaaki, Miyoshi, Takushi, Yamamoto, Norio, Yamahara, Kohei, Ito, Juichi, Nakagawa, Takayuki
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051152/
https://ncbi.nlm.nih.gov/pubmed/24884926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-15-66
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