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Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

The M2-1 protein of human metapneumovirus (HMPV) is a zinc-binding transcription antiterminator which is highly conserved among pneumoviruses. We report the structure of tetrameric HMPV M2-1. Each protomer features a N-terminal zinc finger domain and an α-helical tetramerization motif forming a rigi...

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Hlavní autoři: Leyrat, Cedric, Renner, Max, Harlos, Karl, Huiskonen, Juha T, Grimes, Jonathan M
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051120/
https://ncbi.nlm.nih.gov/pubmed/24842877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02674
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