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A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation
Familial dysautonomia (FD) is characterized by severe and progressive sympathetic and sensory neuron loss caused by a highly conserved germline point mutation of the human ELP1/IKBKAP gene. Elp1 is a subunit of the hetero-hexameric transcriptional elongator complex, but how it functions in disease-v...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Company of Biologists
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4050699/ https://ncbi.nlm.nih.gov/pubmed/24917501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.107797 |
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