Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia®) in canine mast cell tumor

BACKGROUND: Mast cell tumors (MCTs) are the most common skin tumors in dogs and exhibit variable biologic behavior. Mutations in the c-kit proto-oncogene are associated with the tumorigenesis of MCTs, resulting in growth factor-independent and constitutive phosphorylation of the KIT receptor tyrosin...

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Autors principals: Halsey, Charles HC, Gustafson, Daniel L, Rose, Barbara J, Wolf-Ringwall, Amber, Burnett, Robert C, Duval, Dawn L, Avery, Anne C, Thamm, Douglas H
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049511/
https://ncbi.nlm.nih.gov/pubmed/24885200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-6148-10-105
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