Regulatory T Cells and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment Undergo Fas-Dependent Cell Death during IL-2/αCD40 Therapy

Fas ligand expression in certain tumors has been proposed to contribute to immunosuppression and poor prognosis. However, immunotherapeutic approaches may elicit the Fas-mediated elimination of immunosuppressive regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) within tumors th...

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Bibliographic Details
Main Authors: Weiss, Jonathan M., Subleski, Jeff J., Back, Tim, Chen, Xin, Watkins, Stephanie K., Yagita, Hideo, Sayers, Thomas J., Murphy, William J., Wiltrout, Robert H.
Format: Artigo
Language:Inglês
Published: AAI 2014
Subjects:
Immunotherapy and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048774/
https://ncbi.nlm.nih.gov/pubmed/24808361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400404
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