Cardiac Spliced BIN1 Folds T-tubule Membrane, Controlling Ion Flux and Limiting Arrhythmia

Cardiomyocyte T-tubules are important for regulating ionic flux. Bridging Integrator 1 (BIN1) is a T-tubule protein associated with calcium channel trafficking that is down-regulated in failing hearts. Here we find that cardiac T-tubules normally contain dense protective inner membrane folds that ar...

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Detalhes bibliográficos
Main Authors: Hong, TingTing, Yang, Huanghe, Zhang, Shan-Shan, Cho, Hee Cheol, Kalashnikova, Mariya, Sun, Baiming, Zhang, Hao, Bhargava, Anamika, Grabe, Michael, Olgin, Jeffrey, Gorelik, Julia, Marbán, Eduardo, Jan, Lily Y., Shaw, Robin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048325/
https://ncbi.nlm.nih.gov/pubmed/24836577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3543
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