Small Intestinal Intraepithelial TCRγδ(+) T Lymphocytes Are Present in the Premature Intestine but Selectively Reduced in Surgical Necrotizing Enterocolitis

BACKGROUND: Gastrointestinal barrier immaturity predisposes preterm infants to necrotizing enterocolitis (NEC). Intraepithelial lymphocytes (IEL) bearing the unconventional T cell receptor (TCR) γδ (γδ IEL) maintain intestinal integrity and prevent bacterial translocation in part through production...

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Main Authors: Weitkamp, Jörn-Hendrik, Rosen, Michael J., Zhao, Zhiguo, Koyama, Tatsuki, Geem, Duke, Denning, Timothy L., Rock, Michael T., Moore, Daniel J., Halpern, Melissa D., Matta, Pranathi, Denning, Patricia W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048281/
https://ncbi.nlm.nih.gov/pubmed/24905458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099042
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