Kineret(®)/IL-1ra Blocks the IL-1/IL-8 Inflammatory Cascade during Recombinant Panton Valentine Leukocidin-Triggered Pneumonia but Not during S. aureus Infection

OBJECTIVES: Community-acquired Staphylococcus aureus necrotizing pneumonia is a life-threatening disease. Panton Valentine Leukocidin (PVL) has been associated with necrotizing pneumonia. PVL triggers inflammasome activation in human macrophages leading to IL-1β release. IL-1β activates lung epithel...

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Detalhes bibliográficos
Main Authors: Labrousse, Delphine, Perret, Magali, Hayez, Davy, Da Silva, Sonia, Badiou, Cédric, Couzon, Florence, Bes, Michèle, Chavanet, Pascal, Lina, Gérard, Vandenesch, François, Croisier-Bertin, Delphine, Henry, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048174/
https://ncbi.nlm.nih.gov/pubmed/24905099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097546
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