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The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy

Epilepsy is a neurological disorder characterized by a hyperexcitable brain tissue and unpredictable seizures, i.e., aberrant firing discharges in large neuronal populations. It is well established that proinflammatory cytokines, in addition to their canonical involvement in the immune response, hav...

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Hlavní autoři: Chiavegato, Angela, Zurolo, Emanuele, Losi, Gabriele, Aronica, Eleonora, Carmignoto, Giorgio
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047964/
https://ncbi.nlm.nih.gov/pubmed/24936172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00155
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