Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

BACKGROUND: Transforming growth factor, beta (TGFB) signal is considered to be a tumor suppressive pathway based on the frequent genomic deletion of the SMAD4 gene in pancreatic cancer (PC); however; the role of the activin signal, which also belongs to the TGFB superfamily, remains largely unclear....

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Autors principals: Togashi, Yosuke, Sakamoto, Hiroki, Hayashi, Hidetoshi, Terashima, Masato, de Velasco, Marco A, Fujita, Yoshihiko, Kodera, Yasuo, Sakai, Kazuko, Tomida, Shuta, Kitano, Masayuki, Ito, Akihiko, Kudo, Masatoshi, Nishio, Kazuto
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047430/
https://ncbi.nlm.nih.gov/pubmed/24886203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-126
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