PA1b Inhibitor Binding to Subunits c and e of the Vacuolar ATPase Reveals Its Insecticidal Mechanism

The vacuolar ATPase (V-ATPase) is a 1MDa transmembrane proton pump that operates via a rotary mechanism fuelled by ATP. Essential for eukaryotic cell homeostasis, it plays central roles in bone remodeling and tumor invasiveness, making it a key therapeutic target. Its importance in arthropod physiol...

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Main Authors: Muench, Stephen P., Rawson, Shaun, Eyraud, Vanessa, Delmas, Agnès F., Da Silva, Pedro, Phillips, Clair, Trinick, John, Harrison, Michael A., Gressent, Frédéric, Huss, Markus
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047407/
https://ncbi.nlm.nih.gov/pubmed/24795045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541250
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