Isoform-selective Inhibition of Facilitative Glucose Transporters: ELUCIDATION OF THE MOLECULAR MECHANISM OF HIV PROTEASE INHIBITOR BINDING

Pharmacologic HIV protease inhibitors (PIs) and structurally related oligopeptides are known to reversibly bind and inactivate the insulin-responsive facilitative glucose transporter 4 (GLUT4). Several PIs exhibit isoform selectivity with little effect on GLUT1. The ability to target individual GLUT...

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Detalhes bibliográficos
Main Authors: Hresko, Richard C., Kraft, Thomas E., Tzekov, Anatoly, Wildman, Scott A., Hruz, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047383/
https://ncbi.nlm.nih.gov/pubmed/24706759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528430
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