Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

Previous studies have demonstrated that Artemin (ARTN) functions as a cancer stem cell (CSC) and metastatic factor in mammary carcinoma. Herein, we report that ARTN mediates acquired resistance to trastuzumab in HER2-positive mammary carcinoma cells. Ligands that increase HER2 activity increased ART...

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Detalhes bibliográficos
Principais autores: Ding, Keshuo, Banerjee, Arindam, Tan, Sheng, Zhao, JunSong, Zhuang, Qian, Li, Rui, Qian, Pengxu, Liu, Suling, Wu, Zheng-Sheng, Lobie, Peter E., Zhu, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047380/
https://ncbi.nlm.nih.gov/pubmed/24737320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529552
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