Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in ALS transgenic mice

The target disconnection theory of amyotrophic lateral sclerosis (ALS) pathogenesis suggests disease onset is initiated by a peripheral pathological event resulting in neuromuscular junction loss and motoneuron (MN) degeneration. Pre-symptomatic mSOD1(G93A) mouse facial MN (FMN) are more susceptible...

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Main Authors: Haulcomb, Melissa M., Mesnard, Nichole A., Batka, Richard J., Alexander, Thomas D., Sanders, Virginia M., Jones, Kathryn J.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046277/
https://ncbi.nlm.nih.gov/pubmed/24424947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.23538
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