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Metabolic engineering of lactate dehydrogenase rescues mice from acidosis
Acidosis causes millions of deaths each year and strategies for normalizing the blood pH in acidosis patients are greatly needed. The lactate dehydrogenase (LDH) pathway has great potential for treating acidosis due to its ability to convert protons and pyruvate into lactate and thereby raise blood...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4046128/ https://ncbi.nlm.nih.gov/pubmed/24898534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05189 |
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