Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic–pituitary–adrenal axis in rats

Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic–pituitary–adrenal (HPA) axis plays a protective role in the body's defence against sepsis. Sepsis induces a profound systemic immune response and cytokines serve as excellent markers for sepsis as they act as...

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Autori principali: Basharat, Saadia, Parker, Jennifer A, Murphy, Kevin G, Bloom, Stephen R, Buckingham, Julia C, John, Christopher D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Bioscientifica Ltd 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045222/
https://ncbi.nlm.nih.gov/pubmed/24578293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-13-0249
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