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Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner

PURPOSE: Protein kinase inhibitors (PKI) have become prominent agents in cancer therapeutics. However, the specificity for target kinase inhibition can be poor and unwanted effects can emerge in combination regimens. The PKI emodin, for instance, can produce mixed results when combined with cisplati...

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Bibliografiske detaljer
Main Authors: Kurokawa, Tetsuji, He, Guangan, Siddik, Zahid H.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045215/
https://ncbi.nlm.nih.gov/pubmed/19529937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1045-2
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