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Deep brain stimulation of the subthalamic nucleus reestablishes neuronal information transmission in the 6-OHDA rat model of parkinsonism

Pathophysiological activity of basal ganglia neurons accompanies the motor symptoms of Parkinson's disease. High-frequency (>90 Hz) deep brain stimulation (DBS) reduces parkinsonian symptoms, but the mechanisms remain unclear. We hypothesize that parkinsonism-associated electrophysiological...

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Main Authors: Dorval, Alan D., Grill, Warren M.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044335/
https://ncbi.nlm.nih.gov/pubmed/24554786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00713.2013
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