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Timed Deletion of Twist1 in the Limb Bud Reveals Age-Specific Impacts on Autopod and Zeugopod Patterning

Twist1 encodes a transcription factor that plays a vital role in limb development. We have used a tamoxifen-inducible Cre transgene, Ubc-CreERT2, to generate time-specific deletions of Twist1 by inducing Cre activity in mouse embryos at different ages from embryonic (E) day 9.5 onwards. A novel fore...

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Detalhes bibliográficos
Main Authors: Loebel, David A. F., Hor, Angelyn C. C., Bildsoe, Heidi K., Tam, Patrick P. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044014/
https://ncbi.nlm.nih.gov/pubmed/24893291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098945
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