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Epidemiological mechanisms of genetic resistance to kuru

Transmissible spongiform encephalopathies (TSEs), such as kuru, are invariably fatal neurodegenerative conditions caused by a malformation of the prion protein. Heterozygosity of codon 129 of the prion protein gene has been associated with increased host resistance to TSEs, although the mechanism by...

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Bibliografiske detaljer
Main Authors: Atkins, Katherine E., Townsend, Jeffrey P., Medlock, Jan, Galvani, Alison P.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043168/
https://ncbi.nlm.nih.gov/pubmed/23740487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2013.0331
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