Selective inhibition of angiotensin receptor signaling through Erk1/2 pathway by a novel peptide

A seven-amino acid peptide (PEP7) is encoded within a short open reading frame within exon 2 (E2) in the 5′-leader sequence (5′LS) upstream of the rat ANG 1a-receptor (rAT(1a)R) mRNA. A chemically synthesized PEP7 markedly inhibited ANG II-induced Erk1/2 activation in cell culture by 62% compared wi...

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Bibliografske podrobnosti
Main Authors: Liu, Jun, Yosten, Gina L. C., Ji, Hong, Zhang, Dan, Zheng, Wei, Speth, Robert C., Samson, Willis K., Sandberg, Kathryn
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2014
Teme:
Fluid and Electrolyte Homeostasis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043133/
https://ncbi.nlm.nih.gov/pubmed/24523339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00562.2013
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