A negative feedback loop mediated by the Bcl6–cullin 3 complex limits Tfh cell differentiation

Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh) cell differentiation of antigen-stimulated CD4(+) T cells. Intriguingly, we found that Bcl6 was also highly and transiently expressed during the CD4(+)CD8(+) (double positive [DP]) stage of T cell development, in associ...

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Hlavní autoři: Mathew, Rebecca, Mao, Ai-ping, Chiang, Andrew H., Bertozzi-Villa, Clara, Bunker, Jeffrey J., Scanlon, Seth T., McDonald, Benjamin D., Constantinides, Michael G., Hollister, Kristin, Singer, Jeffrey D., Dent, Alexander L., Dinner, Aaron R., Bendelac, Albert
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042651/
https://ncbi.nlm.nih.gov/pubmed/24863065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132267
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