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Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition

N-methyl-d-aspartate receptors (NMDARs) have been linked to schizophrenia because agents that bind the receptor, like ketamine and phencyclidine, are capable of inducing schizophrenia-like symptoms. Here we show that the amino acid homocysteine (HCY), which is increased in the blood of schizophrenia...

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Detalhes bibliográficos
Main Authors: Bolton, Andrew D., Phillips, Marnie A., Constantine-Paton, Martha
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042420/
https://ncbi.nlm.nih.gov/pubmed/23864370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00809.2012
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