Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway

BACKGROUND: Left ventricular hypertrophy (LVH) is a potent risk factor for sudden death and congestive heart failure. METHODS: We tested the effect of sorafenib, a multikinase inhibitor (10 mg/kg, given orally, starting 2 days prior to banding, till sacrifice on day 14), on the development of LVH fo...

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Detalhes bibliográficos
Main Authors: Daryadel, Arezoo, Bogdanova, Anna, Gassmann, Max, Mueller, Xavier, Zünd, Gregor, Seifert, Burkhardt, Lehalle, Christine, Frossard, Nelly, Tavakoli, Reza
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042218/
https://ncbi.nlm.nih.gov/pubmed/24885948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1749-8090-9-81
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