Protective Epitopes of the Plasmodium falciparum SERA5 Malaria Vaccine Reside in Intrinsically Unstructured N-Terminal Repetitive Sequences

The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we have previously shown the inhibitory effects of SE36 specific antibodies on in vitro parasite growth and the negative correla...

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Main Authors: Yagi, Masanori, Bang, Gilles, Tougan, Takahiro, Palacpac, Nirianne M. Q., Arisue, Nobuko, Aoshi, Taiki, Matsumoto, Yoshitsugu, Ishii, Ken J., Egwang, Thomas G., Druilhe, Pierre, Horii, Toshihiro
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041889/
https://ncbi.nlm.nih.gov/pubmed/24886718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098460
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