A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

DNA-damage response machinery is crucial to maintain the genomic integrity of cells, by enabling effective repair of even highly lethal lesions such as DNA double-strand breaks (DSBs). Defects in specific genes acquired through mutations, copy-number alterations or epigenetic changes can alter the b...

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Detalhes bibliográficos
Main Authors: Liu, Chao, Srihari, Sriganesh, Cao, Kim-Anh Lê, Chenevix-Trench, Georgia, Simpson, Peter T., Ragan, Mark A., Khanna, Kum Kum
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041457/
https://ncbi.nlm.nih.gov/pubmed/24792170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku284
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