Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures

Scopolamine is a pharmaceutically important tropane alkaloid extensively used as an anticholinergic agent. Here, we report the simultaneous introduction and overexpression of genes encoding the rate-limiting upstream enzyme putrescine N-methyltransferase (PMT) and the downstream enzyme hyoscyamine 6...

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Detalhes bibliográficos
Main Authors: Zhang, Lei, Ding, Ruxian, Chai, Yourong, Bonfill, Mercedes, Moyano, Elisabet, Oksman-Caldentey, Kirsi-Marja, Xu, Tiefeng, Pi, Yan, Wang, Zinan, Zhang, Hanming, Kai, Guoyin, Liao, Zhihua, Sun, Xiaofen, Tang, Kexuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC404123/
https://ncbi.nlm.nih.gov/pubmed/15084741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401391101
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