Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

Recent studies have shown that genes involved in oxidative phosphorylation (OXPHOS) exhibit reduced expression in skeletal muscle of diabetic and prediabetic humans. Moreover, these changes may be mediated by the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Mootha, Vamsi K., Handschin, Christoph, Arlow, Dan, Xie, Xiaohui, St. Pierre, Julie, Sihag, Smita, Yang, Wenli, Altshuler, David, Puigserver, Pere, Patterson, Nick, Willy, Patricia J., Schulman, Ira G., Heyman, Richard A., Lander, Eric S., Spiegelman, Bruce M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2004
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404086/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15100410/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401401101
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