Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

Using methodology developed herein, it is found that reactive persulfides and polysulfides are formed endogenously from both small molecule species and proteins in high amounts in mammalian cells and tissues. These reactive sulfur species were biosynthesized by two major sulfurtransferases: cystathi...

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Hauptverfasser: Ida, Tomoaki, Sawa, Tomohiro, Ihara, Hideshi, Tsuchiya, Yukihiro, Watanabe, Yasuo, Kumagai, Yoshito, Suematsu, Makoto, Motohashi, Hozumi, Fujii, Shigemoto, Matsunaga, Tetsuro, Yamamoto, Masayuki, Ono, Katsuhiko, Devarie-Baez, Nelmi O., Xian, Ming, Fukuto, Jon M., Akaike, Takaaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040604/
https://ncbi.nlm.nih.gov/pubmed/24733942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321232111
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