Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

The subthalamic nucleus (STN) is a key area of the basal ganglia circuitry regulating movement. We identified a subpopulation of neurons within this structure that coexpresses Vglut2 and Pitx2, and by conditional targeting of this subpopulation we reduced Vglut2 expression levels in the STN by 40%,...

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Detalhes bibliográficos
Main Authors: Schweizer, Nadine, Pupe, Stéfano, Arvidsson, Emma, Nordenankar, Karin, Smith-Anttila, Casey J. A., Mahmoudi, Souha, Andrén, Anna, Dumas, Sylvie, Rajagopalan, Aparna, Lévesque, Daniel, Leão, Richardson N., Wallén-Mackenzie, Åsa
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040590/
https://ncbi.nlm.nih.gov/pubmed/24821804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323499111
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