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Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae
In mammalian cells, perturbations in DNA replication result in chromosome breaks in regions termed “fragile sites.” Using DNA microarrays, we mapped recombination events and chromosome rearrangements induced by reduced levels of the replicative DNA polymerase-α in the yeast Saccharomyces cerevisiae....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040566/ https://ncbi.nlm.nih.gov/pubmed/24799712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406847111 |
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