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Reaction pathways and free energy profiles for cholinesterase-catalyzed hydrolysis of 6-monoacetylmorphine

As the most active metabolite of heroin, 6-monoacetylmorphine (6-MAM) can penetrate into the brain for the rapid onset of heroin effects. The primary enzymes responsible for the metabolism of 6-MAM to the less potent morphine in humans are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)...

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Autori principali: Qiao, Yan, Han, Keli, Zhan, Chang-Guo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040391/
https://ncbi.nlm.nih.gov/pubmed/24595354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob42464b
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