IFN-γ Attenuates Hypoxia-Inducible Factor (HIF) Activity in Intestinal Epithelial Cells through Transcriptional Repression of HIF-1β

Numerous studies have revealed that hypoxia and inflammation occur coincidentally in mucosal disorders, such as inflammatory bowel disease. During inflammation, epithelial-expressed hypoxia-inducible factor (HIF) serves an endogenously protective function. In this study, we sought to explore how muc...

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Hlavní autoři: Glover, Louise E., Irizarry, Karina, Scully, Melanie, Campbell, Eric L., Bowers, Brittelle E., Aherne, Carol M., Kominsky, Douglas J., MacManus, Christopher F., Colgan, Sean P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040106/
https://ncbi.nlm.nih.gov/pubmed/21199896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001442
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