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Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways

Emerging evidence suggests that neuronal responses to N-methyl-d-aspartate (NMDAR) activation/inactivation are influenced by subunit composition. For example, activation of synaptic NMDAR (comprised of GluN2A > GluN2B) phosphorylates cAMP-response-element-binding protein (CREB) at Ser 133, induce...

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Detalhes bibliográficos
Main Authors: Rittase, W. Bradley, Dong, Yu, Barksdale, DaRel, Galdzicki, Zygmunt, Bausch, Suzanne B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039624/
https://ncbi.nlm.nih.gov/pubmed/24769103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2014.04.002
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