APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD

OBJECTIVES: To investigate whether APOE ε4 carriers have higher hippocampal atrophy rates than non-carriers in Alzheimer's disease (AD), mild cognitive impairment (MCI) and controls, and if so, whether higher hippocampal atrophy rates are still observed after adjusting for concurrent whole-brai...

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Bibliographic Details
Main Authors: Manning, Emily N., Barnes, Josephine, Cash, David M., Bartlett, Jonathan W., Leung, Kelvin K., Ourselin, Sebastien, Fox, Nick C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039513/
https://ncbi.nlm.nih.gov/pubmed/24878738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097608
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