Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation

PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated wit...

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Autors principals: Leal, Mariana Ferreira, Cirilo, Priscila Daniele Ramos, Mazzotti, Tatiane Katsue Furuya, Calcagno, Danielle Queiroz, Wisnieski, Fernanda, Demachki, Samia, Martinez, Margarita Cortes, Assumpção, Paulo Pimentel, Chammas, Roger, Burbano, Rommel Rodríguez, Smith, Marília Cardoso
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039508/
https://ncbi.nlm.nih.gov/pubmed/24879411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098583
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