Extracellular activation of Wnt signaling through epigenetic dysregulation of Wnt inhibitory factor-1 (Wif-1) is associated with pathogenesis of adrenocortical tumor

Wnt/β-catenin signaling is considered to be an essential regulator of adrenocortical oncogenesis. Wnt inhibitory factor-1 (Wif-1), an extracellular regulator of Wnt signaling, is frequently down-regulated by hypermethylation of the promoter CpG. We investigated epigenetic regulation of Wif-1 and its...

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Detalhes bibliográficos
Main Authors: Mitsui, Yozo, Yasumoto, Hiroaki, Nagami, Taichi, Hiraki, Miho, Arichi, Naoko, Ishikawa, Noriyoshi, Araki, Asuka, Maruyama, Riruke, Tanaka, Yuichiro, Dahiya, Rajvir, Shiina, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039156/
https://ncbi.nlm.nih.gov/pubmed/24755523
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