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GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure

Rho family GTPases regulate many morphogenetic processes during vertebrate development including neural tube closure. Here we report a function for GEF-H1/Lfc/ArhGEF2, a RhoA-specific guanine nucleotide exchange factor that functions in neurulation in Xenopus embryos. Morpholino-mediated depletion o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Itoh, Keiji, Ossipova, Olga, Sokol, Sergei Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038946/
https://ncbi.nlm.nih.gov/pubmed/24681784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.146811
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