Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway

Dysregulation of Sonic hedgehog (Shh) signaling has been implicated in glioma pathogenesis. Yet, the role of this pathway in gliomagenesis remains controversial because of the lack of relevant animal models. Using the cytokeratin 5 promoter, we ectopically expressed a constitutively active zebrafish...

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Detalhes bibliográficos
Main Authors: Ju, B, Chen, W, Spitsbergen, J M, Lu, J, Vogel, P, Peters, J L, Wang, Y-D, Orr, B A, Wu, J, Henson, H E, Jia, S, Parupalli, C, Taylor, M R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038393/
https://ncbi.nlm.nih.gov/pubmed/24686726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.10
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