Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast carcinomas

Genetic and epigenetic (DNA methylation, histone modifications, microRNA expression) crosstalk promotes inactivation of tumor suppressor genes or activation of oncogenes by gene loss/hypermethylation or duplications/hypomethylation, respectively. The 8p11-p12 chromosomal region is a hotspot for geno...

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Detalhes bibliográficos
Main Authors: Parris, T Z, Kovács, A, Hajizadeh, S, Nemes, S, Semaan, M, Levin, M, Karlsson, P, Helou, K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038389/
https://ncbi.nlm.nih.gov/pubmed/24662924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.8
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