Genetic and immune factors underlying the efficacy of cetuximab and panitumumab in the treatment of patients with metastatic colorectal cancer

Efficacy of monoclonal anti-EGFR antibodies (cetuximab, panitumumab) used in combination with chemotherapy or alone has been demonstrated in clinical trials of patients with mCRC. Both drugs block signaling EGFR pathway in malignant cells (blocking ligand binding and EGFR dimerization). Obtaining tr...

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Hlavní autoři: Krawczyk, Paweł Adam, Kowalski, Dariusz M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Termedia Publishing House 2013
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037996/
https://ncbi.nlm.nih.gov/pubmed/24876815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/wo.2013.38566
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