Integrative Transcriptomic and Proteomic Analysis of Osteocytic Cells Exposed to Fluid Flow Reveals Novel Mechano-Sensitive Signaling Pathways

Osteocytes, positioned within bone's porous structure, are subject to interstitial fluid flow upon whole bone loading. Such fluid flow is widely theorized to be a mechanical signal transduced by osteocytes, initiating a poorly understood cascade of signaling events mediating bone adaptation to...

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Autores principales: Govey, Peter M., Jacobs, Jon M., Tilton, Susan C., Loiselle, Alayna E., Zhang, Yue, Freeman, Willard M., Waters, Katrina M., Karin, Norman J., Donahue, Henry J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037855/
https://ncbi.nlm.nih.gov/pubmed/24720889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiomech.2014.03.022
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