Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1 + ionomycin in IL-7 + IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2

Regression of established tumors can be induced by adoptive immunotherapy (AIT) with tumor draining lymph node (DLN) lymphocytes activated with bryostatin and ionomycin (B/I). We hypothesized that B/I-activated T cells cultured in IL-7 + IL-15 might proliferate and survive in culture better than cel...

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Autores principales: Le, Hanh K., Graham, Laura, Miller, Catriona H. T., Kmieciak, Maciej, Manjili, Masoud H., Bear, Harry Douglas
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer-Verlag 2009
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037402/
https://ncbi.nlm.nih.gov/pubmed/19198835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-009-0666-y
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