Hydroxycarbamide Decreases Sickle Reticulocyte Adhesion to Resting Endothelium by Inhibiting Endothelial Lutheran/Basal Cell Adhesion Molecule (Lu/BCAM) through Phosphodiesterase 4A Activation

Vaso-occlusive crises are the main acute complication in sickle cell disease. They are initiated by abnormal adhesion of circulating blood cells to vascular endothelium of the microcirculation. Several interactions involving an intricate network of adhesion molecules have been described between sick...

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Main Authors: Chaar, Vicky, Laurance, Sandrine, Lapoumeroulie, Claudine, Cochet, Sylvie, De Grandis, Maria, Colin, Yves, Elion, Jacques, Le Van Kim, Caroline, El Nemer, Wassim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036286/
https://ncbi.nlm.nih.gov/pubmed/24616094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506121
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